Stem cell transplantation for type 1 diabetes mellitus

Stem cell transplantation for type 1 diabetes mellitus

BACKGROUND The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide beta cell regeneration. CONCLUSION High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mell...

Stem cell therapies for type 1 diabetes mellitus.

The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this resp...

Stem Cell Therapy for Type-1 Diabetes Mellitus

Stem Cell Therapy for Type-1 Diabetes Mellitus

The role of hematopoietic stem cell transplantation for type 1 diabetes mellitus

Júlio C. Voltarelli Carlos Eduardo B. Couri Maria Carolina Rodrigues Ana Beatriz P. L. Stracieri Daniela A. Moraes Fabiano Pieroni George Navarro Maria Isabel A. Madeira Belinda P. Simões In this review, we present 1) scientific basis for the use of high dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes mel...